Volume 14•Issue 5

Biotech/Pharma investors employ valuation methods to support capital deployment that consider the costs of drug development, projected sales and risks of failure. Often, the major focus for valuation is placed on the likely success rates of taking a ...

What is this summary about? Hypophosphatasia (HPP for short) is a rare inherited condition that can present at any stage of life, with symptoms typically being more severe in cases that manifest earlier, such as during infancy or childhood. This article ...

What is this summary about? This is a plain language summary of an article originally published in the journal Sleep Medicine. Narcolepsy is a sleep condition in which people have periods of extreme sleepiness during the day. People with narcolepsy may ...

Aim: The choice of covariates in unanchored matching-adjusted indirect comparisons (MAICs) of single-arm cancer trials with time-to-event outcomes remains a challenge. Currently, there is a lack of a systematic approach for validating the selection of ...

Aim: Despite the availability of novel treatment options for patients with triple-class exposed/refractory multiple myeloma , there is a lack of consensus on the optimal regimen. A previous unanchored matching-adjusted indirect comparison (MAIC) of the ...

Aim: Under the newly instituted health technology assessment (HTA) regulation (HTAR), health technology developers must build evidence packages that meet the needs for both the upcoming EU joint clinical assessment (JCA) and national decision-making. In-...

Aim: Approximately 20% of patients with uncomplicated appendicitis receive antibiotics as a first-line treatment; this study explores the impacts of expanding patient uptake of first-line antibiotics for appendicitis treatment. Materials & methods: We ...

Aim: To evaluate healthcare resource utilization (HCRU) and costs for US commercially insured adult and pediatric patients with sickle cell disease (SCD) and matched non-SCD cohorts. Materials & methods: Patients with ≥3 SCD diagnosis codes (D57.0–...

Aim: Several therapies have recently been licensed for the treatment of patients with moderately to severely active ulcerative colitis (UC). To provide comparative evidence of newly available treatments, Bayesian network meta-analyses were conducted to ...