An impact evaluation of two modes of care for sickle cell disease crises
Publication: Journal of Comparative Effectiveness Research
Abstract
Aim: To estimate the economic impacts of increased use of specialty care infusion centers for treating adults experiencing vaso-occlusive crises. Methods: A Markov model is developed to estimate the impact of expanding use of specialty care infusion centers to treat vaso-occlusive crises compared to emergency department care. Results: Access to infusion centers for sickle cell disease could result in savings over US$1.9 billion in formal medical costs and over US$2 billion in societal costs, based on uptake assumptions over 10 years. Conclusion: Expansion of adult sickle cell disease centers across the nation could lead to considerably better economic outcomes in the form of reduced costs and hospital length of stay in addition to improved clinical outcomes as reported in the existing literature.
Plain language summary
Specialty care centers for sickle cell disease crises offer improved care and patient experience over typical emergency department care. This paper is based on a recent study, which compared the treatment for sickle cell disease crises at specialty centers and emergency departments by estimating the potential economic impacts of expanded specialty care centers. We estimate the impacts of increased specialty care use on healthcare costs, caregiver time, patient time and employer absenteeism costs. When 35% of the USA adult population acquires access to a specialty sickle cell disease center, a total savings over US$1.9 billion can be obtained after 10 years.
Supplementary Material
File (appendix a.docx)
- Download
- 17.79 KB
References
Papers of special note have been highlighted as: • of interest; •• of considerable interest
1.
Tanabe P, Myers R, Zosel A et al. Emergency department management of acute pain episodes in sickle cell disease. Acad. Emerg. Med. 14(5), 419–425 (2008).
2.
Silbergleit R, Jancis MO, McNamara RM. Management of sickle cell pain crisis in the emergency department at teaching hospitals. J. Emerg. Med. 17(4), 625–30 (1999).
•• Prospective cohort study which compares care for adults with sickle cell disease (SCD) between the emergency department and specialty care center.
3.
Lanzkron S, Little J, Wang H et al. Treatment of acute pain in adults with sickle cell disease in an infusion center versus the emergency department: a multi-center prospective cohort study. Ann. Intern. Med. 174(9), 1207–1213 (2021).
• Provides an overview of the organization of an adult SCD program, including the perspectives of providers and patients.
4.
Rousseau R, Weisberg DF, Gorero J et al. Utilization, financial outcomes and stakeholder perspectives of a re-organized adult sickle cell program. PLoS ONE 15(7), e0236360 (2020).
5.
Okpala I, Thomas V, Westerdale N et al. The comprehensive care of sickle cell disease. Eur. J. Haematol. 68(3), 157–162 (2002).
6.
Yang YM, Shah AK, Watson M, Mankad VN. Comparison of costs to the health sector of comprehensive and episodic health care for sickle cell disease patients. Public Health Rep. 110(1), 80–86 (1995).
•• Defines various models of SCD care and the essential components for each.
7.
Kanter J, Smith WR, Desai PC et al. Building access to care in adult sickle cell disease: defining models of care, essential components, and economic aspects. Blood 4(16), 3804–3813 (2020).
8.
PCORI (Patient-Centered Outcomes Research Institute). Expanding access to the infusion center model for people living with SCD (2020). Available from: www.pcori.org/research-results/2019/expanding-access-infusion-center-model-people-living-scd
9.
U.S. Census Bureau. National population by characteristics, 2010–2019: population estimates by age (18+) (2020). Available from: www.census.gov/data/tables/time-series/demo/popest/2010s-national-detail.html#par_textimage_1537638156
10.
Hassell KL. Population estimates of sickle cell disease in the U.S. Am. J. Prev. Med. 38(4), S512–S521 (2010).
11.
Brousseau D, Owens P, Mosso A et al. Acute care utilization and rehospitalizations for sickle cell disease. JAMA 303(13), 1288–1294 (2010).
12.
National Center for Health Statistics. Martin JA, Hamilton BE, Osterman MJK, Driscoll AK. Births: final data for 2018. National Vital Statistics Reports. MD, USA 68(13), 1–46 (2020).
13.
Paulukonis S, Eckman J, Snyder A et al. 367–377 Defining sickle cell disease mortality using a population-based surveillance system, 2004 through 2008. Public Health Rep. 131(2), (2016).
14.
Brousseau D, Panepinto J, Nimmer M, Hoffman RG. The number of people with sickle-cell disease in the United States: national and state estimates. Am. J. Hematol. 85(1), 77–80 (2009).
• Reviews quality of life, economic costs, and utilization costs for adults with SCD across a variety of studies.
15.
Lee S, Vania DK, Bhor M et al. (2020). Patient-reported outcomes and economic burden of adults with sickle cell disease in the United States: a systematic review. Int. J. Gen. Med. 13, 361–377 (2020).
16.
Lanzkron S, Carroll CP, Haywood C. The burden of emergency department use for sickle-cell disease: an analysis of the national emergency department sample database. Am. J. Hematol. 85(10), 797– 799 (2010).
17.
HCUPnet, Healthcare Cost and Utilization Project. Free health care statistics. Agency for Healthcare Research and Quality, Rockville, MD. (n.d.). Available from: https://hcupnet.ahrq.gov/
18.
HHS AHRQ (U.S. Department of Health and Human Services, Agency for Healthcare Research and Quality). MEPS HC-201: 2017 full year consolidated data file [Dataset]. (2019). Available from: https://meps.ahrq.gov/mepsweb/data_stats/download_data_files_detail.jsp?cboPufNumber=HC-201
19.
Brown AM, Decker SL, Selck FW. Emergency department visits and proximity to patients' residences, 2009–2010. NCHS data brief, No 192. National Center for Health Statistics, MD, USA (2015).
20.
IRS (Internal Revenue Service). IRS issues standard mileage rates for 2020. (2019). Available from: www.irs.gov/newsroom/irs-issues-standard-mileage-rates-for-2020
21.
Lanzkron S, Little J, Field J et al. Increased acute care utilization in a prospective cohort of adults with sickle cell disease. Blood 2(18), 2412–2417 (2018).
22.
U.S. DOL BLS (U.S. Department of Labor, Bureau of Labor Statistics). Earnings, median usual weekly earnings, employed full time, 2018, by quarter. Labor force statistics from the Current Population Survey. Series ID LEU0252881500. Available from: www.bls.gov/cps/ (2018).
23.
Bazell C, Dieguez G, Ferro C, Mirchandani H. A claims-based analysis of sickle cell disease: prevalence, disease, complications, and costs. (2019). Available from: http://assets.milliman.com/ektron/A_claims-based_analysis_of_sickle_cell_disease_Prevalence_disease_complications_and_costs.pdf
24.
Huo J, Xiao H, Garg M, Shah C, Wilkie DJ, Mainous A III. PSY10: the economic burden of sickle cell disease in the United States. Value Health 21(Suppl. 2), S108 (2018).
25.
Molokie RE, Montminy C, Dionisio C et al. Opioid doses and acute care utilization outcomes for adults with sickle cell disease: ED versus acute care unit. Am. J. Emerg. Med. 36(1), 88–92 (2018).
26.
Zhang H, Kilaru AS, Meisel ZF, Bao Y. Prescription drug monitoring program mandates and opioids dispensed following emergency department encounters for patients with sickle cell disease or cancer with bone metastasis. JAMA 326(3), 274–276 (2021).
27.
Limenis E. Improving outpatient follow-up after discharge from hospital for patients with sickle cell disease at high risk for readmission. Paediatr. Child Health 22(Suppl. 1), e18 (2017).
28.
Shaiova L, Wallenstein D. Outpatient management of sickle cell pain with chronic opioid pharmacotherapy. JAMA 96(7), 984–986 (2004).
29.
Zaidi A, Estepp J, Shah N et al. A reanalysis of pain crises data from the pivotal l-glutamine in sickle cell disease trial. Contemp. Clin. Trials 110, 106546 (2021).
Information & Authors
Information
Published In
Pages: 399 - 409
PubMed: 35187950
Copyright
© 2022 Future Medicine Ltd.
History
Received: 19 October 2021
Accepted: 10 January 2022
Published online: 21 February 2022
Keywords:
Topics
Authors
Funding Information
Patient-Centered Outcomes Research Institute: IDIQ-SOW #16-INSIGHT-AOSEPP-ENG
Metrics & Citations
Metrics
Article Usage
Article usage data only available from February 2023. Historical article usage data, showing the number of article downloads, is available upon request.
Citations
How to Cite
An impact evaluation of two modes of care for sickle cell disease crises. (2022) Journal of Comparative Effectiveness Research. DOI: 10.2217/cer-2021-0257
Export citation
Select the citation format you wish to export for this article or chapter.
Citing Literature
- Paul Telfer, Kofi A. Anie, Stella Kotsiopoulou, Laura Aiken, Stephen Hibbs, Carol Burt, Sara Stuart-Smith, Sanne Lugthart, The acute pain crisis in sickle cell disease: What can be done to improve outcomes?, Blood Reviews, 10.1016/j.blre.2024.101194, 65, (101194), (2024).
