Development of a novel prognostic score for breast cancer patients using mRNA expression of CHAC1
Abstract
Aim: To develop a prognostic score for primary breast cancer patients integrating conventional predictors and the novel biomarker CHAC1 to aid adjuvant chemotherapy decisions. Patients & methods: A prognostic score for overall survival was developed using: conventional predictors from a dataset of 1777 patients and the weight of CHAC1 mRNA expression from an independent dataset of 106 patients using multivariate Cox regression. Results: The new score includes: CHAC1 mRNA expression, age, tumor size, HER2 neu status, lymph node status and degree of malignancy. Using a cut-off value of 11 score points, 10-year survival was 82% in low-risk (n = 34) and 43% in high-risk patients (n = 72). The addition of CHAC1 resulted in 16% reclassification. Conclusion: Including CHAC1 in prognostic prediction may aid (and change) personalized treatment selection.
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Published online: 19 September 2017
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Development of a novel prognostic score for breast cancer patients using mRNA expression of CHAC1
. (2017) Journal of Comparative Effectiveness Research. DOI: 10.2217/cer-2017-0015
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