Tr14 gel for the treatment of acute ankle sprains: a plain language summary of the TRAUMED trial
Publication: Journal of Comparative Effectiveness Research
Abstract
What is this summary about?
This is a summary of an article discussing the results of the TRAUMED trial, which was originally published in the Journal of Clinical Medicine. This trial studied how well Tr14 gel helped with ankle sprains compared with either a dummy treatment (placebo) or a common painkiller called diclofenac.
What were the results of this trial, and what do they mean?
The results of this trial showed that Tr14 was effective at reducing pain caused by an acute or sudden ankle sprain compared with placebo and worked just as well as diclofenac. The results also suggested that Tr14 led to faster pain relief and improved foot and ankle function compared with placebo and was at least as effective as diclofenac.
Clinical Trial Registration: NCT06192420
This is an abstract of the Plain Language Summary of Publication article.
To read the full Plain Language Summary of this article, click here to view the PDF.
Financial disclosure
The TRAUMED trial was sponsored by Heel GmbH.
Competing interests disclosure
Ludger Gerdesmeyer and Gino Kerkhoffs received consultancy fees to participate in Advisory Board meetings during the conception, conduct and analysis of this clinical trial. Konstantin Cesnulevicius, Myron Schultz and Alta Smit are employees of Heel GmbH. Helmut Pabst has no competing interests to report. The authors of this summary have no other competing interests or relevant affiliations with any organization or entity with the subject matter or materials discussed in the summary apart from those disclosed.
Writing disclosure
Medical writing assistance for this summary was provided by Oxford PharmaGenesis, UK, and was supported by Heel GmbH.
Open access
This work is licensed under the Creative Commons Attribution 4.0 License. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/
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© 2025 The authors. This work is licensed under the Creative Commons Attribution 4.0 License
History
Received: 20 February 2025
Accepted: 9 May 2025
Published online: 5 June 2025
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How to Cite
Tr14 gel for the treatment of acute ankle sprains: a plain language summary of the TRAUMED trial. (2025) Journal of Comparative Effectiveness Research. DOI: 10.57264/cer-2025-0018
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