Effectiveness of using an extensively hydrolyzed casein formula supplemented with Lactobacillus rhamnosus GG compared with an extensively hydrolysed whey formula in managing cow’s milk protein allergic infants
Publication: Journal of Comparative Effectiveness Research
Abstract
Aim: To assess the comparative effectiveness of two hypoallergenic formulae in managing cow’s milk allergic infants. Materials & methods: This study retrospectively analyzed the case records of 940 formula-fed cow’s milk allergic infants in the UK extracted from The Health Improvement Network database. Results: At 24 months after starting a formula, 77% of infants fed an extensively hydrolyzed casein formula supplemented with Lactobacillus rhamnosus GG (eHCF LGG; n = 470) were estimated to have been successfully managed compared with 63% of matched infants who were fed an extensively hydrolyzed whey formula (eHWF; n = 470; p < 0.001). Additionally, significantly more eHWF-fed infants were estimated to be experiencing gastrointestinal symptoms, eczema and asthma (7.1 vs 3.1%; p < 0.02) at 24 months. Conclusion: First-line management of newly diagnosed cow’s milk allergic infants with eHCF LGG may slow down the allergic march seen in cow’s milk allergic children.
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Pages: 1317 - 1326
PubMed: 31526139
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© 2019 Julian Guest. This work is licensed under the Attribution-NonCommercial-NoDerivatives 4.0 Unported License
History
Received: 5 July 2019
Accepted: 12 August 2019
Published online: 17 September 2019
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Effectiveness of using an extensively hydrolyzed casein formula supplemented with Lactobacillus rhamnosus GG compared with an extensively hydrolysed whey formula in managing cow’s milk protein allergic infants. (2019) Journal of Comparative Effectiveness Research. DOI: 10.2217/cer-2019-0088
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