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Research Article
5 May 2023

Advantages of robotic arm-assisted total hip arthroplasty: a 90-day episode-of-care clinical utility and cost analysis

Abstract

Aim: Determine the clinical utility and economic differences over a 90-day period between robotic arm-assisted total hip arthroplasty (RATHA) and manual total hip arthroplasty (MTHA). Methods: Leveraging a nationwide commercial payer database, pre-covid THA procedures were identified. Following a 1:5 propensity score match, 1732 RATHA and 8660 MTHA patients were analyzed. Index costs, index lengths of-stay, and 90-day episode-of-care utilization and costs were evaluated. Results: Episode of care costs for RATHA was found to be $1573 lower compared with MTHA (p < 0.0001). Post-index hospital utilization was significantly less likely to occur for RATHA compared with MTHA. Total index costs were also significantly lower for RATHA versus MTHA (p < 0.0001). Conclusion: Index and post-index EOC hospital utilization and costs were lower for RATHA compared with MTHA.

Tweetable abstract

A 90-day episode-of-care analysis of 1732 robotic arm-assisted and 8660 manual THAs reveals costs were $1573 lower for RATHA compared with MTHA and hospital utilization was less.
#stryker #makosmartrobotics #orthopaedics #totalhipreplacement
Total hip arthroplasty (THA) is one of the most successful operations provided to patients. One study found that 58% of THAs should last at least 25 years, indicating strong long-term implant survivorship [1]. However, there are still some common complications, such as component malpositioning that surgeons need to be highly cognizant of during both preoperative planning and surgery [2]. To help optimize implant positioning and restore leg length, several different technological devices are available [3]. Robotic arm-assisted total hip arthroplasty, in particular, helps facilitate acetabular component placement in the desired position for each individual patient. In fact, studies have shown that robotic arm-assisted hip arthroplasties are associated with a greater chance of placing components in the universally accepted hip safe zones [4]. In association with real time haptic feedback, CT scan-based robotic arm-assisted THA (RATHA) can more reliably reproduce and is more accurate and precise in achieving the planned hip center of rotation [5]. Although robotic technology can have potential intraoperative and patient specific advantages, a major consideration, especially given today's healthcare climate, is the economic impact of using this technology versus simply using manual techniques.
The evaluation of the economic impact of changes in care delivery is playing a larger role in healthcare decision making today. A substantial emphasis is placed on providing patients with the most appropriate level of care while ensuring that there is a fair assessment of value of that care [6]. This emphasis is even greater for total joint arthroplasty, given that these surgeries are performed often and on an elective basis. Although there is limited cost-consideration-based data for RATHA, several studies have shown cost savings as well as patient outcome advantages when utilizing robotic arm assistance for total knee arthroplasty [7,8]. In one study by Gregory et al., the authors utilized a large national database comparing robotic-assisted (n = 4135) versus manual (n = 4135) total knee arthroplasties and found significant cost savings based on a 90-day episode of care (EOC) analysis ($29,984 vs $31,280, p < 0.0001) [9]. In another study, Cool et al., also found significant 90-day EOC cost savings for patients who underwent robotic-assisted versus manual total knee arthroplasty ($2391 less for robotic TKA [p < 0.0001]) [8]. The authors also identified that a major reason driving these cost savings for robotic-assisted TKA patients was the overall decreased utilization of post-acute services.
Given that patients more commonly report higher satisfaction with their hip arthroplasties as compared with their knee arthroplasties [10], and given the intraoperative advantages of more accurately placing implants leading to potentially improve postoperative function, there is reason to believe that incorporating robotic technology in total hip arthroplasty can further help increase the economic advantages. The purpose of this study was to perform a 90-day EOC clinical utility and cost analysis study of CT scan-based RATHA versus manual total hip arthroplasty (MTHA) patients, with a focus on the payer perspective and reduced use of the expensive hospital setting during both the index and post-index periods. Specifically, we evaluated: 1) Index costs; 2) Index lengths-of-stay; 3) 90-day post-index resource utilization and costs; and 4) Overall 90-day EOC costs.

Materials & methods

Data source

In order to capture the cost impact from a payer perspective, The Blue Health Intelligence (BHI) nationwide commercial insurance database (Health Intelligence Company, LLC, IL, USA) was utilized to capture all patient data. This database contains data regarding medical and pharmacy services provided to more than 234 million unique patients' medical and pharmaceutical claims. Utilizing a medical claims database provides the unique advantage of being able to capture all billable aspects of the longitudinal patient journey, which is not necessarily possible with hospital-specific or index-focused datasets. This data source contains a population of commercially insured patients, with over 90% being less than 65 years old.

Patient Selection

All patients who had hospital admissions under DRG codes 469 and 470 were isolated, yielding a total of 185,181 patients. Patients were then filtered directly based on the following ICD codes for THA: 0SR9019, 0SR901A, 0SR901Z, 0SR9029, 0SR902A, 0SR902Z, 0SR9039, 0SR903A, 0SR903Z, 0SR9049, 0SR904A, 0SR904Z, 0SR90J9, 0SR90JA, 0SR90JZ, 0SRB019, 0SRB01A, 0SRB01Z, 0SRB029, 0SRB02A, 0SRB02Z, 0SRB039, 0SRB03A, 0SRB03Z, 0SRB049, 0SRB04A, 0SRB04Z, 0SRB0J9, 0SRB0JA, and 0SRB0JZ, yielding 152,570 patients. Further selection was performed for patients who underwent their THA between 1 April 2018 and 30 September 2019, extracting 56,433 patients from the database. Next, patients who did not have an inpatient admission for DRG 469 and 470 within 60 days prior or 90 days after their THA were selected for inclusion (n = 53,515).
From this cohort of 53,515 THA patients, two study populations were identified: a CT scan-based robotic arm-assisted THA (RATHA) cohort and a manual THA (MTHA) cohort. The RATKA population was identified through an ICD-10 code indicative of a robotic-assisted procedure and a CT scan within 60 days prior to the THA procedure. Patients who did not have a robotic-assisted procedure and a CT scan were deemed manual cases. The patient population was further limited to the first THA event during the study timeframe and those that had continuous enrollment during the post-operative 90-day follow-up. Patients were required to have at least one follow-up service on a post-index basis. Finally, patients who had an index admission cost of at least $12,000 for MS-DRG 470 or at least $19,000 for MS-DRG 469 were selected (Figure 1). This threshold was selected to ensure that the payer cost was at or above the average Medicare payment in order to avoid scenarios associated with major patient responsibilities or other underpayment situations that could not be controlled for in the study.
Figure 1. Patient selection for the robotic and manual cohorts.
THA: Total hip arthroplasty.

Propensity score matching

Patients in each cohort were propensity score matched (PSM) in a 1:5 ratio of robotic to manual cases using the greedy nearest-neighbor algorithm applied to propensity score probabilities estimated by logistic regression with independent variables based on age, sex, comorbidities, census division based on US Census bureau divisions (i.e., New England, Middle Atlantic, East North Central, etc.), and geography (i.e., urban, rural, etc.). Comorbidities included: chronic obstructive pulmonary disease; diabetes; coronary artery disease; cancer; smoking; obesity; hypertension; bone density issues; osteoarthritis; and functional mobility issues. (Table 1).
Table 1. Pre-and-post match demographic and comorbidity profile for study cohorts.
CharacteristicsPre-match characteristicsPost-match characteristics
 RATHA (n = 1784)MTHA (n = 44,510)% difference (% points)p-valueRATHA (n = 1732)MTHA (n = 8660)% difference (% points)p-value
Age group (years)
  <403.53%2.85%240.01123.52%3.34%50.9957
  40–4911.60%10.29%13 11.72%11.91%-2 
  50–5415.58%14.22%10 15.59%16.09%-3 
  55–5926.85%26.13%3 26.96%27.07%0 
  60–6431.61%33.61%-6 31.52%31.26%1 
  65–698.13%9.38%-13 8.08%7.90%2 
  70+2.69%3.52%-24 2.60%2.45%6 
  Men50.28%51.41%-20.358750.35%51.11%-10.5626
Comorbidities
  Chronic obstructive pulmonary disease4.04%4.19%-40.80943.81%2.89%320.0460
  Diabetes11.43%13.48%-150.013011.09%10.98%10.8996
  Coronary artery disease7.79%7.70%10.89197.79%7.41%50.5821
  Cancer0.78%1.11%-300.24470.69%0.48%440.2720
  Smoking12.72%12.83%-10.942412.41%11.71%60.4150
  Obesity31.17%32.19%-30.379531.12%31.55%-10.7339
  Hypertension54.65%54.69%00.980754.56%55.21%-10.6339
  Bone density issues4.93%3.73%320.01134.85%4.57%60.6159
  Osteoarthritis99.33%97.65%2<0.000199.48%99.69%00.1797
  Functional mobility issues8.63%7.23%190.02898.66%7.77%110.2229
Census Division
  New England8.80%6.18%42<0.00018.66%8.71%-10.9969
  Middle Atlantic15.19%16.08%-6 15.18%15.46%-2 
  East North Central13.00%17.24%-25 12.70%12.15%5 
  West North Central3.59%7.68%-53 3.52%3.63%-3 
  South Atlantic10.71%20.69%-48 10.91%11.28%-3 
  East South Central15.02%7.89%90 15.36%14.99%2 
  West South Central20.63%10.87%90 20.79%21.34%-3 
  Mountain5.55%5.07%9 5.60%5.20%8 
  Pacific7.29%8.01%-9 7.04%7.06%0 
  Unknown0.22%0.28%-21 0.23%0.20%15 
Geography
  Urban87.11%88.83%-20.049087.12%88.52%-20.0513
  Rural9.59%8.00%20 9.58%9.15%5 
  Unknown3.31%3.17%4 3.29%2.33%41 
MTHA: Manual total hip arthroplasty; RATHA: Robotic arm-assisted total hip arthroplasty.

Outcomes evaluated

The outcomes evaluated in this study was 90-day episode-of-care costs, utilization trends, and index lengths-of-stay. These costs consisted of index facility and professional fees, CT-scan costs, as well as post-index costs, such as inpatient, outpatient, pharmacy, professional, and other costs. ‘Other costs’ involved patient utilization of any of the following resources: emergency rooms, ambulatory surgical centers, independent clinics, skilled nursing facilities, home health usages, inpatient psychiatric facilities, comprehensive inpatient and outpatient rehabilitation centers, and/or independent laboratory testings.

Data analyses

All data were extracted from the BHI database and evaluated utilizing SAS Enterprise Guide 7.1 (SAS Institute Inc., NC, USA). Descriptive analyses were performed for qualitative variables. Mann–Whitney U tests were performed to compare differences between cohorts for the above listed outcomes evaluated. Outliers were identified and removed by converting episode of care costs to natural logarithm values and were assumed to be distributed as log-normal. An interquartile based method was used with a cutoff point as 1.5-times the interquartile range at both the upper and lower bound.

Results

Index costs

The overall mean index costs for the RATHA cohort was found to be $1,297 lower than that of the MTHA cohort ($31,507 vs $32,804; p < 0.0001). This trend in costs persisted when comparing mean facility fees ($27,103 vs $28,839; difference: $1736; p < 0.0001), and professional fees ($3902 vs $3965; difference: $63; p = 0.0007). The further breakdown of these costs is represented in Table 2.
Table 2. Index costs breakdown.
Cost measurementRATHA costs (n = 1732)MTHA costs (n = 8660)Cost difference (RATHA–MTHA)Std mean differencep-value
Index THA admission – facility$27,103$28,839-$1736-6.02%-0.1806<0.0001
Index THA admission – professional$3902$3965-$63-1.59%-0.03140.0007
CT Scan$502
Total index costs$31,507$32,804-$1297-3.95%-0.1266<0.0001
MTHA: Manual total hip arthroplasty; RATHA: Robotic arm-assisted total hip arthroplasty; THA: Total hip arthroplasty.
On Mann–Whitney U Testing, index costs facility and professional, total index costs, all tended to be significantly lower for the robotic as compared with the manual cohort (Table 2).

Lengths-of-Stay

RATHA patients were found to be associated with a shorter length-of-stay as compared with MTHA patients (1.51 vs 1.71 days; p < 0.0001) (Table 3). Moreover, one-day stays were significantly more prevalent for RATHA patients (65.24 vs 58.98%; p < 0.0001), while stays of 3+ days were significantly less prevalent (7.97 vs 11.34%; p < 0.0001) (Table 4).
Table 3. Mean lengths-of-stays between cohorts.
RATHA LOS (n = 1732)MTHA LOS (n = 8660)LOS difference (RATHA–MTHA)Std mean differencep-value
1.511.71-0.20-11.66%-0.1379<0.0001
LOS: Length of stay; MTHA: Manual total hip arthroplasty; RATHA: Robotic arm-assisted total hip arthroplasty.
Table 4. Lengths-of-stay distribution between cohorts.
LOSRATHA (n = 1732)MTHA (n = 8660)p-value
1 day1130 (65.24%)5108 (58.98%)<0.0001
2 days464 (26.79%)2570 (29.68%)0.0163
3+ days138 (7.97%)982 (11.34%)<0.0001
LOS: Length of stay; MTHA: Manual total hip arthroplasty; RATHA: Robotic arm-assisted total hip arthroplasty.

90-day post-index resource utilization & costs

For inpatient services, 31.66% fewer RATHA patients needed inpatient care (p 0.0203), resulting in 35.93% fewer readmissions (p = 0.0204) for this cohort. Moreover, 7.85% fewer patients needed hospital outpatient services (p = 0.0038), leading to 22.25% fewer hospital outpatient encounters (p = 0.0002) across the RATHA cohort. The reduction in hospital costs (both inpatient and hospital outpatient services) were driven by reduced post-index utilization of these services in the RATHA cohort compared with the manual cohort (Table 5). Overall, the RATHA cohort had lower costs associated with 90-day post-index resource utilization ($3929 vs $4205; difference: $276; p = 0.1086). Specifically, the RATHA cohort had fewer inpatient ($377 vs $506; difference: $129; p = 0.0160), outpatient ($801 vs $999; difference: $198; p = 0.0010) and pharmacy ($418 vs $454; difference: $37; p = 0.1242) costs compared with MTHA. Higher costs associated with RATHA were professional ($1691 vs $1641; difference: $42; p = 0.0001) and other costs ($643 vs $597; difference: $46; p < 0.0001) (Table 6).
Table 5. 90-day post-index resource utilization.
Place of serviceRATHA utilization (n = 1732)MTHA utilization (n = 8660)Utilization difference (% difference)p-value
 PatientsAvg visits per patientPatientsAvg visits per patientPatientsAvg visits per patientPatients, %Avg visits per patient
Inpatient2.31%0.02663.38%0.0415-31.66%-35.93%0.02030.0204
Hospital Outpatient44.98%1.191748.81%1.5327-7.85%-22.25%0.00380.0002
Pharmacy62.99%6.312960.83%5.62363.55%12.26%0.09410.0006
Professional99.31%13.067698.90%11.87030.41%10.09%0.1509<0.0001
Other47.52%1.139137.88%0.951425.45%19.74%<0.0001<0.0001
Other settings include: emergency room, skilled nursing facilities, home health, ambulatory surgical centers, independent clinics, inpatient psychiatric facilities, comprehensive inpatient rehabilitation, comprehensive outpatient rehabilitation, independent labs and other facility services.
Avg: average; MTHA: Manual total hip arthroplasty; RATHA: Robotic arm-assisted total hip arthroplasty.
Table 6. 90-day post-index costs.
Place of serviceRATHA costs (n = 1732)MTHA costs (n = 8660)Cost differences (RATHA–MTHA)Std mean differencep-value
Inpatient$377$506-$129-25.59%-0.04100.0160
Hospital Outpatient$801$999-$198-19.83%-0.08950.0010
Pharmacy$418$454-$37-8.09%-0.02150.1242
Professional$1691$1649$422.56%0.01960.0001
Other$643$597$467.64%0.0335<0.0001
Total Post-Index Costs$3929$4205-$276-6.56%-0.04900.1086
Other settings include: emergency room, skilled nursing facilities, home health, ambulatory surgical centers, independent clinics, inpatient psychiatric facilities, comprehensive inpatient rehabilitation, comprehensive outpatient rehabilitation, independent labs and other facility services.
MTHA: Manual total hip arthroplasty; RATHA: Robotic arm-assisted total hip arthroplasty.

Overall Index plus 90-Day Episode-of-Care Costs

Total index costs (facility, professional, CT-scan costs) plus post-index resource utilization costs were $1573 lower for the RATHA cohort compared with MTHA ($35,436 vs $37,009; p < 0.0001) (Table 7).
Table 7. Overall 90-day episode-of-care costs.
 RATHA costs (n = 1732)MTHA costs (n = 8660)Cost difference (RATHA–MTHA)Std mean differencep-value
Total EOC costs (index + 90-Day)$35,436$37,009-$1573-4.25%-0.1345<0.0001
MTHA: Manual total hip arthroplasty; RATHA: Robotic arm-assisted total hip arthroplasty.

Discussion

Robotic arm-assisted total hip arthroplasty has been shown to have several intraoperative advantages leading to more optimal and reliably reproducible component positioning [11]. Additionally, clinical studies have shown improved patient reported outcomes and satisfaction scores for RATHA compared with MTHA as well as reductions in adverse events such as post-operative dislocation [4,12,22]. Currently, there are limited data comparing the clinical utility and costs of care using this technology-assisted surgery as compared with traditional manual techniques. Therefore, this study compared overall 90-day episode of care costs including index costs, post-index resource utilization and costs and lengths-of-stays between CT scan-based RATHA versus MTHAs. The data from this study indicate significant cost savings to the payer for patients who underwent RATHA as compared with MTHA patients. These patients tended to have lower associated postoperative resource utilization, specifically around post-index use of the hospital, and shorter index lengths-of-stays. The lengths-of-stays found in this study represent more modern lengths-of-stay with contemporary postoperative protocols compared with what has been presented in prior studies. Specifically, robotic-assisted care was associated with significantly more single day stays than the manual cohort, as well as significantly fewer stays of three days or more. It is notable that this LOS profile lends itself to a meaningful and imminent transition to outpatient THAs and the associated cost-efficiencies of this less restrictive setting. Therefore, these data are likely more representative of current costs in today's healthcare climate.
We suspect that in addition to the potential cost savings from decreased post-index hospital utilizations and shorter lengths-of-stay, the intra-operative advantages involved with robotic arm-assisted technology may also play a role in facilitating a more expedited postoperative recovery. The advantages include more optimal component planning and positioning, and ability to prepare the acetabulum in a more controlled manner due to the robotic arm minimizing inadvertent surrounding bony or soft tissue damage, as well as the ability to perform a single reaming as opposed to multiple reaming in MTHA, while still ensuring that the acetabular component is appropriately medialized [12]. These benefits in surgical technique may potentially help the body more quickly acclimate to the new prosthesis and therefore improve post-operative recovery [11–14]. Studies have shown reduced blood loss, greater acetabular bone preservation, and better restoration of the hip center-of-rotation for RATHA compared to MTHA. Shibanuma and colleagues compared the early recovery of 30 RATHA patients with 30 computer-navigated THAs (CNTHA) and found that RATHA patients had improved early clinical recovery including reduced pain on post-operative days 7, 10 and 14, fewer days to independent walking, and significantly higher Harris Hip scores compared to CNTHA [14].
There are some limitations to this study. As a large database study, there are always the potential errors for data entry and coding. Additionally, since multiple codes are needed to identify robotic THA patients, there is a chance that some patients were missed during the initial data collection phase. This study was also retrospective in nature, so the selection of patients to undergo robotic versus manual THAs could not be controlled. Furthermore, other important peri-operative factors were not included for analysis, such as anesthesia type, pain management, and/or physical therapies provided. Nevertheless, this study represents a large, nationwide sample indicative of the current state of robotic THA clinical utility and economics. Notably, since this data was collected from a large insurance database a true, real world cost analysis could be performed, further helping to substantiate the findings.
There are other studies in the literature that support the findings from this analysis. In a study by Pierce et al., 938 RATHAs from a private payer database were propensity score matched to 4670 MTHAs and compared based on 90-day episode of care costs, index costs, lengths-of-stay, and post-index rehabilitation utilizations [15]. The authors found that RATHA was significantly associated with fewer instances of post-index inpatient rehabilitation or skilled nursing facility admissions compared with MTHA. RATHA patients also utilized fewer home health agency visits compared with MTHA patients in their analysis. Overall, they found that total 90-day EOC costs for RATHA patients were significantly less than that of MTHA patients (difference: $785; p = 0.0095).
In another study by Maldonado et al., the authors created a Markov model to analyze cumulative costs and utilities between RATHA versus MTHAs [16]. The group found that the RATHA cohort was more cost effective relative to MTHA for cumulative medical and private insurance payer costs over a 5-year period. For Medicare patients, RATHAs saved a mean of $945, and for private insurance saved payers $1810 compared with MTHA. Additionally, RATHA had slightly more health utility (0.04 quality-adjusted life year).
In a study by Clement et al. the authors compared 40 RATHA patients versus 80 propensity score matched MTHA patients and compared several patient satisfaction outcome surveys as well as component placement based on the Lewinnek and Callanan safe zones, as well as ability to restore leg lengths [17]. The group found that the Oxford hip and Forgotten Joint Scores were significantly greater in the RATHA cohort as compared with the MTHA cohort. Importantly, no patients in the RATHA cohort were dissatisfied, however, 6 MTHA patients were dissatisfied. Overall, RATHA was associated with a greater rate of safe zone component positioning (p ≤ 0.003) as well as leg length restoration (p < 0.001) compared to MTHA.
Some studies in the literature have identified a lack of advantage for RATHA. A study by Emara et al., found RATHAs to potentially be more costly than MTHAs (robotic: $18,416 vs manual: $17,266; p < 0.001) [18]. However, the data were from the National Inpatient Sample which only evaluates the in-hospital period, and not cumulative episode-of-care costs, which is widely considered a better overall economic marker of value. Additionally, this study revealed a mean length-of-stay for robotic THA patients to be 2.2 days and manual THA patients to be 2.3 days, which is substantially longer than the lengths-of-stay identified in our report and is less representative of modern THA care pathways. In a study by Kirchner et al., the authors utilized the same database as the aforementioned study and similarly found mean RATHA index costs to be greater than that for MTHA patients [19]. Although the lengths-of-stay for the robotic cohort was shorter than that for the manual cohort, the costs reported only represent inpatient hospital costs, and not overall 90-day episode-of-care costs, which are a better economic indicator in today's value-based world. Furthermore, all of these studies do not account for the fact that new technologies can assist in shifting inpatient surgical cases to the outpatient arena which further decreases cost, but is not captured in these inpatient analyses.

Conclusion

Robotic arm-assisted total hip arthroplasty has been shown in the literature to have several intraoperative advantages, especially pertaining to optimal component positioning [11]. The added benefits of more precise and accurate acetabular cup placement have also been shown to help improve component survivorship, decrease complications, and likely influence greater patient satisfaction [20,21]. Additionally, the literature has shown less complication rates for adverse events such as dislocation between robotic-assisted and manual THAs [22]. What has not been well-elucidated are the potential clinical utility and economic benefits of this technology. Our study revealed that RATHA patients used fewer hospital services in the post-index period, had greater average cost savings based on their 90-day episodes of care, as well as shorter index lengths-of-stay compared with MTHA. In an era of increased focus on value in healthcare, CT-based robotic assisted surgery appears to both improve quality and decrease costs. Based on these data, RATHA shows not only advantages for component placement and improved outcomes for patients, but also advantages for the costs of care over a 90-day time period. Furthermore, our results are in agreement with similar payer perspective analyses. Overall, RATHA shows promising advancements for clinical and economic optimization of THA. Payers would likely benefit from encouraging the use of CT-based robotic technology in THA.
Summary points
Total hip arthroplasty procedures provide strong long-term implant survivorship, however, there are still complications that can be limited and efficiencies gained in care delivery with technological devices, such as robotic technology.
Even though robotic technology can have potential intraoperative and patient-specific advantages, the economic burden to health plans needs to be considered.
Robotic arm-assisted total hip arthroplasty helps facilitate acetabular component placement in the desired position for each individual patient.
The economic value of robotic arm-assisted total hip arthroplasty (RATHA) for Medicare patients has been previously quantified, but the impact to commercial insurers has yet to be determined.
This analysis of health plan costs over the total episode-of-care showed RATHA to be statistically significantly lower than procedures performed manually.
During the post 90-day period, fewer RATHA patients required inpatient or outpatient hospital care compared to manual total hip arthroplasty and utilized statistically significantly fewer services across these settings.
This study shows that commercial payers would benefit financially from the use of CT-scan-based robotic technologies for total hip arthroplasties.

Acknowledgments

The authors acknowledge L Mills (Baker Tilly, US, LLP).

Financial & competing interests disclosure

This study was sponsored by Stryker. W Barsoum is a paid consultant of Stryer and receives royalties from Stryker, Zimmer, Biomet and Arthrex. D Gregory is a Principal and K Needham is an employee of Baker Tilly US, LLP, which received consulting fees from the sponsor. M Mont and D Jacofsky are paid consultants of Stryker. A Coppolecchia is an employee of Stryker and owns stock in Stryker. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

Institutional review board is not required for this type of study and specific human subjects were not investigated; therefore, informed consent was not required.

Open access

This work is licensed under the Attribution-NonCommercial-NoDerivatives 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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