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The Evidence Base Post

Infographic – Target practice: Making real-world evidence credible through the target trial framework

  • The Evidence Base

As expectations for real-world evidence (RWE) continue to evolve, there is increasing pressure to generate findings that are not only relevant, but also methodologically robust and decision ready. The target trial framework (TTF) has emerged as a key approach to meeting this need, providing a structured way to design observational studies that can support causal inference.

This infographic explores how the TTF brings rigor and transparency to observational research, enabling real-world data to be used to answer causal questions with increased credibility. It outlines the core principles of the framework, highlights where it can be applied across the product lifecycle and provides practical guidance on how to implement it effectively in RWE generation.

Explore the infographic below to learn more. For a PDF version, click here.


Published as part of the Evidence Insights, "From trials to reality: Understanding the target trial framework in evidence generation".



Published as part of the Evidence Insights, "From trials to reality: Understanding the target trial framework in evidence generation", sponsored by Adigens Health.