Designing trustworthy RWE: How policy, data infrastructure, and AI shape real‑world impact
Healthcare policy, AI, and real-world evidence (RWE) are increasingly interconnected, creating new opportunities and new challenges for evidence generation. As organizations adopt AI-enabled analytics and work with increasingly complex healthcare data, questions around governance, transparency, and implementation have become central to generating evidence that decision-makers can trust.
This Deep Dive explores how policy priorities, data infrastructure, and integrated evidence ecosystems are shaping the future of evidence generation. Through insights from Myla Maloney, John Knapp, Todd Wilkes and Ariann Stone of Premier, the article examines the foundations needed to generate decision-grade RWE across research, regulatory, and clinical decision-making.
Readers will gain a better understanding of:
- How healthcare policy is influencing evidence needs
- Why governance is essential for trustworthy AI-enabled research
- How integrated evidence ecosystems support continuous learning across healthcare
- How these capabilities can be applied in research, regulatory, and clinical settings
Read the full Deep Dive here.
About the speakers
Myla Maloney, MBA, BCMAS
Chief Growth Officer, Premier Applied Sciences
Myla Maloney, MBA, is Chief Growth Officer for Premier Applied Sciences, the data and research division of Premier. With 24 years of experience in the healthcare industry, Maloney supports Premier’s mission of transforming healthcare by leading collaborations between Premier Applied Sciences and life sciences organizations to improve population health. Maloney joined Premier in 2018. She previously served as Chief Commercial Officer for Premier Applied Sciences as well as Premier's Vice President of Strategic Supplier Engagement, during which she partnered with leading biopharmaceutical and IT companies. Maloney received her Bachelor of Science in business administration and Master of Business Administration from East Carolina University.
John Knapp
Vice President, Advocacy, Premier, Inc.
John Knapp serves as Vice President, Advocacy in Premier’s Washington, DC office. In this role, John serves as the primary contact for Premier with Capitol Hill lawmakers. With more than 20 years of experience in healthcare advocacy, John advances policy proposals to support the transformation to high-quality, cost-effective healthcare. Prior to joining Premier, John worked for the Children’s Hospital Association and the firm of O’Neill, Athy & Casey. John is a graduate of Connecticut College and the University of Texas at Austin.
Todd Wilkes
Vice President and Chief Technology Officer, Premier, Inc.
Todd Wilkes is Vice President and Chief Technology Officer at Premier, where he leads technology strategy, enterprise data platforms, analytics, and digital transformation initiatives. His experience spans healthcare technology, cloud modernization, data engineering, and advanced analytics. Todd is focused on enabling innovative, data driven solutions that improve healthcare outcomes and support evidence-based decision-making.
Ariann Stone
Vice President, Business Development and Strategic Relationships, Premier Applied Sciences
Ariann Stone is the Vice President of Business Development and Strategic Relationships for Premier Applied Sciences, the research and analytics division of Premier. She is responsible for innovation, strategy, and business partnerships. Stone joined Premier in 2015, serving as a member of the Performance Services sales leadership team, with responsibilities in channel partner business development and engagement, and government sales. Her professional experience spans 18 years working in health information technology and strategic partnerships.
Sponsorship for this Deep Dive was provided by Premier Applied Sciences.